Study title

Treatment Factors Associated With Survival in Early-Stage Oral Cavity Cancer

journal

JAMA Otolaryngology- Head and Neck Surgery

study year

2015

QUESTION

Is there an association between treatment variables and survival in stage I and II oral cavity squamous cell carcinoma (OCSCC)?

Study DESIGN

Retrospective cohort study

STUDY GROUPS

Factors investigated:

Radiation therapy, chemotherapy, neck dissection, surgical margins, hospital type/case volume, insurance

Population

Patients with stage I or II OCSCC (n=6,830)

Inclusion criteria

Patients with stage I or II OCSCC

Exclusion criteria

Patients who did not undergo surgery

Multiple malignant primary tumours

Undocumented pathologic stage

Follow-up

N/A

Primary endpoint(s)

5-year survival:

- Neck dissection, no radiotherapy, no chemotherapy, case volume >10/year and negative tumour margins all beneficial (p=0.001 for all)

Overall survival:

- Neck dissection (p=0.003), no radiotherapy (p<0.001), no chemotherapy (p=0.03), academic institution (p=0.03) and negative tumour margins (p=0.005) all beneficial

Secondary endpoint(s)

N/A

Weblink

https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2291044

Brief summary

Patients who underwent END had greater survival, reflecting restaging and elimination of patients with occult nodal disease. Positive margins independently associated with decreased survival.

Authors

Luryi et al

Department of Surgery, Yale University School of Medicine, USA